Mdm2: the ups and downs.

نویسندگان

  • T Juven-Gershon
  • M Oren
چکیده

Mdm2 was first described 12 years ago. Interest in this oncogene has risen since its identification as a protein that binds and efficiently inactivates the p53 tumor suppressor protein. This interest was further boosted by the discovery that the mdm2 gene is actually a target for direct transcriptional activation by p53, thus defining an autoregulatory feedback loop for the intracellular modulation of p53 function. Subsequent work has revealed that the Mdm2 protein is engaged in a complex network of regulatory interactions. In addition to p53, these involve several other interesting protein partners, including critical cell cycle regulators such as pRb, E2Fl/DP1, and p19ARF. Through these interactions, Mdm2 now appears to exert a host of effects on cell cycle, apoptosis, and neoplastic transformation. Several recent excellent reviews offer a detailed discussion of the Mdm2 protein and its various functions (1-3). In the present minireview, we will attempt to highlight some exciting new insights into Mdm2, its biochemistry, and its biology.

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عنوان ژورنال:
  • Molecular medicine

دوره 5 2  شماره 

صفحات  -

تاریخ انتشار 1999